Leica S2 vs Canon 5DS

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Larger sensor
Medium format vs 35mm
More sensor area. Bigger is (generally) better.
Bigger pixels
~ 6.00 vs 4.14 microns
Better low-light and dynamic range (all else equal)
More viewfinder magnification
1.08x vs 0.71x
Get a bigger view of the scene through the eye-level viewfinder
Lacks anti-aliasing filter
No Filter vs Filter
Enjoy sharper photos

Lens selection
Excellent vs Limited
Better lens selection gives you more options
External Mic Jack
Jack vs No jack
Improved sound fidelity when shooting video
More cross-type AF points
41 vs 1
Cross-type AF points improve autofocus performance
Newer
10 years vs 15 years old
Newer cameras often support more advanced features
Shoots 24p video
Yes vs No
Gives your movies a big-screen feel
Lighter weight
946g vs 1410g
Lighter weight
More dots on screen
1044k vs 460k dots
Can mean greater resolution or a brighter screen
Shoots 1080p video
Yes vs No
You'll want this if you shoot video
More pixels
50.6 vs 37.5 megapixels
Higher resolution photos
Shoots 60p video
Yes vs No
A faster framerate can give you more editing options
More AF points
61 vs 1
More AF points improve autofocus
Has anti-aliasing filter
Filter vs No Filter
Reduces unsightly moiré in photos
Faster shutter
1/8000 vs 1/4000 sec
Shoot wide open in bright light
Higher extended ISO
12800 vs 1250 ISO
Higher extended ISO can give more low-light flexibility

Eye-level viewfinder
Both provide
You'll be able to frame photos even when the sun is out
Top deck display
Both provide
Check settings with a screen on top of the camera
Pentaprism viewfinder
Both provide
Much better viewfinder picture fidelity
HDMI out
Both provide
Use HDMI output to monitor or review video
Hot shoe
Both provide
Off-camera flashes open new possibilities
Dual card slots
Both provide
Gives you more storage flexibility
Bulb shutter
Both provide
Hold the shutter open manually for long exposures

Focus peaking
Neither provide
Your camera will highlight what's in focus
Tilt-swivel screen
Neither provide
Tilt and swivel the screen for maximum shooting flexibility
In-Camera Image Stabilization
Neither provide
Reduces the effects of camera shake at slower shutter speeds
Touchscreen
Neither provide
Interact with your camera just like your smartphone
In-camera panoramas
Neither provide
Stitches multiple shots into a panoramic photo
Tiltable Screen
Neither provide
Tilt the screen for shooting flexbility
Built-in Wi-Fi
Neither provide
Share your photos wirelessly
NFC
Neither provide
Simplifies pairing your camera with supported phones
Built-in Bluetooth
Neither provide
Always-on wireless connectivity
Built-in GPS
Neither provide
Geotag your photos
On-sensor phase detect
Neither provide
Usually improves live view and video AF performance
Internal flash
Neither provide
Useful in a pinch for fill flash
Headphone jack
Neither provide
Monitor audio recording while you shoot video
Slow-motion videos
Neither provide
Shoot slow-motion videos